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1 Royal Society of Medicine
Общая лексика: Королевское медицинское общество (Великобритания)Универсальный англо-русский словарь > Royal Society of Medicine
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2 Fellow of the Royal Society of Medicine
Общая лексика: член Королевского медицинского общества (Великобритания)Универсальный англо-русский словарь > Fellow of the Royal Society of Medicine
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3 royal
royal ['rɔɪəl]∎ by royal charter par acte du souverain;∎ the royal "we" le "nous" de majesté∎ they gave us a (right) royal welcome ils nous ont accueillis comme des rois;∎ to be in royal spirits être d'excellente humeur∎ that guy is a right royal pain in the neck ce type est un véritable emmerdeur;∎ her whining gives me a royal pain elle me fait vraiment chier avec ses jérémiades;∎ he's a royal idiot c'est un sombre crétin ou un crétin de première∎ royal octavo/quarto in-huit m/in-quarto m raisin2 nounfamiliar = membre de la famille royale;∎ the Royals la famille royale□►► the Royal Academy (of Arts) Académie f royale britannique des beaux-arts;the Royal Academy of Dramatic Art = Conservatoire national d'art dramatique, à Londres;the Royal Academy of Music = conservatoire national de musique, à Londres;the Royal Air Force armée f de l'air britannique;Royal Ascot = événement hippique annuel, étalé sur plusieurs jours, qui entre dans le calendrier mondain de la haute société anglaise;royal assent = signature royale qui officialise une loi;the Royal Ballet = compagnie nationale de ballet qui a son siège à Covent Garden à Londres;royal blue bleu m roi;the Royal British Legion = association britannique d'anciens militaires;royal burgh ville f établie par charte royale;the Royal Canadian Mounted Police la Gendarmerie royale du Canada;the Royal College of Music Collège m royal de musique (école de musique située à Londres);the Royal College of Physicans Collège m royal de médecine (organisation de médecins);the Royal College of Surgeons Collège m royal de chirurgie (organisation de chirurgiens);the Royal College of Veterinary Surgeons Collège m royal de médecine vétérinaire (organisation de vétérinaires);the Royal Commission = commission nommée par le monarque sur recommandation du premier ministre;the Royal Court = théâtre à Londres;Royal Doulton = porcelaine fine anglaise;the Royal Enclosure = tribune de la famille royale à Royal Ascot;the Royal Engineers le génie militaire britannique;the Royal Family la famille royale;Botany royal fern osmonde f royale;Cards royal flush quinte f royale; (in poker) flush m royal;Royal Highland Show = grande foire agricole annuelle qui a lieu à Ingleston, près d'Édimbourg;Your Royal Highness Votre Altesse Royale;∎ His Royal Highness, the Prince of Wales Son Altesse Royale, le prince de Galles;Their Royal Highnesses Leurs Altesses Royales;the Royal Horse Guards = la garde à cheval qui assure la garde du palais et du souverain;British Cookery royal icing = glaçage à base de sucre glace et de blancs d'œufs (utilisé pour les cakes);the Royal Institute of British Architects = institut d'architectes, à Londres;the Royal Institution l'Académie f des sciences britannique;royal jelly gelée f royale;the Royal Mail = la Poste britannique;the Royal Marines les Marines mpl (britanniques);Nautical royal mast mât m de cacatois;the Royal Mile = rue d'Édimbourg qui relie le château au palais de Holyrood;the Royal Mint = la Monnaie britannique, ≃ (l'hôtel m de) la Monnaie;the Royal Navy la marine f nationale britannique;the Royal Opera House l'opéra m de Covent Garden;Botany royal palm palmier m royal;royal prerogative prérogative f du souverain;∎ to exercise the royal prerogative faire acte de souverain;the Royal School of Music École f royale de musique;Royal Scottish Academy Académie f royale écossaise des beaux-arts;the Royal Shakespeare Company = célèbre troupe de théâtre basée à Stratford-on-Avon et à Londres;the Royal Show = le salon annuel de l'agriculture en Grande-Bretagne;the Royal Society l'Académie f des sciences britannique;Royal Society of Medicine Fondation f britannique de médecine;the Royal Society for the Prevention of Cruelty to Animals = société britannique protectrice des animaux, ≃ SPA f;British the Royal Society for the Prevention of Cruelty to Children ≃ Fondation f pour l'enfance;the Royal Society for the Protection of Birds = ligue britannique pour la protection des oiseaux;royal standard = drapeau représentant les armoiries de la couronne britannique, hissé lorsque le monarque est au château;the Royal Tournament = meeting annuel destiné au public organisé par les forces armées, avec entre autres choses des démonstrations de gymnastique;the Royal Ulster Constabulary = corps de police d'Irlande du Nord;the Royal Variety Show = spectacle de variétés organisé à Londres en faveur de la Fédération des artistes de variétés;royal warrant brevet m de fournisseur du souverain;Royal Worcester = porcelaine fine anglaiseⓘ THE ROYAL SOCIETY Cette société à vocation scientifique, fondée par Charles II en 1660, contribua à renforcer la crédibilité des hommes de science, qui jouirent également d'une plus grande liberté. En firent notamment partie Isaac Newton et Robert Boyle. -
4 Donald, Ian
SUBJECT AREA: Medical technology[br]b. 27 December 1910 Paisley, Scotlandd. 19 June 1987 Paglesham, Essex, England[br]Scottish obstetrician and gynaecologist, pioneer of the diagnostic use of ultrasound in medicine.[br]After he received his initial education in Scotland, Donald's family moved to South Africa, where he obtained a BA degree in Cape Town in 1930. After the death of his parents he returned to England, graduating in medicine in 1937. He served in the RAF from 1942 to 1946 and was awarded the MBE for bravery in rescuing air-crews. In 1954, following a fruitful period as Reader and Lecturer at St Thomas's Hospital and the Hammersmith Hospital, he was appointed Regius Professor of Midwifery in Glasgow. It was while at St Thomas's and Hammersmith that he evolved a demand-response respirator for infants. With the assistance of Tom Brown, an engineer, and the company Kelvin Hughes—which had earlier produced ultrasound equipment for detecting flaws in metal castings—he was able to originate, develop and improve the diagnostic use of ultra-sound in obstetrics and gynaecology. The use of this technique rapidly spread into other disciplines. Donald was fortunate in that the procedure proved to have no untoward influence on pregnancy; at the time, little was known of possible side effects.He was the proponent of other advances in the speciality, including laparoscopy, breast-feeding and the preservation of the membranes during labour. An ardent anti-abortionist, his authoritarian Scottish approach made Glasgow a world centre, with himself as a renowned and loved teacher. Despite undergoing three major cardiac interventions, his longevity did not surprise those who knew of his immense vitality.[br]Principal Honours and DistinctionsCBE 1973. Honorary DSc, London and Glasgow Universities. Royal College of Obstetricians and Gynaecologists Eardley Holland Gold Medal. Royal College of Surgeons Victor Bonney Prize. Royal Society of Medicine Blair Bell Gold Medal.Bibliography1958, "Investigation of abdominal masses by pulsed ultrasound", Lancet (with Brown and MacVicar).Numerous other papers in learned journals.Further ReadingObituary, 1987, Lancet (18 July).MG -
5 Tossach, William
SUBJECT AREA: Medical technology[br]b. c. 1700 probably Perthshire, Scotlandd. after 1771 Alloa, Scotland[br]Scottish surgeon, the first to report a case of artificial respiration by mouth.[br]Little is known of Tossach (a Tossach matriculated at Glasgow University in 1727), but in 1771 he published an account of the resuscitation of a miner, James Blair, who had been rescued from a coal-mine fire. Tossach found "there was not the least pulse in either heart or arteries and not the least breathing could be observed; so that he was in all appearance dead, I applied my mouth close to his, and blowed my breath as strong as I could: but having neglected to close his nostrils all the air came out of them: Wherefore taking hold of them with one hand and holding my other on his breast at the left pap I blew again my breath as strong as I could, raising his chest fully with it; and immediately I felt six or seven very quick beats of the heart." Blair recovered consciousness in an hour and walked home within four.[br]Bibliography1771, "A man dead in appearance recovered by distending the lungs with air", Medical Essays and Observations, Edinburgh.Further Reading1794, Transactions of the Royal Humane Society from 1774–1784, London. J.P.Griffin, 1990, "The origins of the Royal Humane Society", Journal of the RoyalSociety of Medicine 83.MG -
6 RSM
1) Общая лексика: relative spectacle magnification, относительное увеличение оптической силы очков2) Компьютерная техника: Removable Storage Management3) Геология: Remote Sensing Manual4) Военный термин: radiation signature measurement, radiation situation map, radiation survey meter, radio squadron, mobile, reconnaissance strategic missile, regimental sergeant-major, rescue mission, runway surface and marking6) Сельское хозяйство: red spider" mite7) Математика: метод анализа на поверхности отклика (response surface method)8) Религия: Religious Sisters Of Mercy9) Железнодорожный термин: Railroad Switching Service of Missouri Incorporated10) Радио: разбираемость, слышимость11) Телекоммуникации: Remote Switching Module (telephony)12) Сокращение: Reconfigurable (microwave) Switching Matrix, Rectangular Spectrum Modulation, Republic Of San Marino, Rotational Signal Modulation, Route Switch Module, Royal Society of Medicine, Royal Society of Musicians of Great Britain13) Университет: Royal School Of Music14) Вычислительная техника: Remote Switching Module16) Иммунология: Regulator Of Secondary Metabolites17) Транспорт: Revolution Speed Meter18) Деловая лексика: Retail Service Merchandiser19) Химическое оружие: Rocket shear machine20) Безопасность: remote surveillance module21) Корма: rapeseed meal22) Фантастика Rabid Space Monkey23) Правительство: Rancho Santa Margarita24) НАСА: Rubber Sealant Membrane25) Программное обеспечение: Really Simple Modeler26) AMEX. Merrill Lynch & Company, Inc. -
7 Thomas, Hugh Owen
SUBJECT AREA: Medical technology[br]b. 1833 Anglesey, North Walesd. 6 January 1891 Liverpool, England[br]Welsh orthopaedic surgeon, a founder of modern orthopaedics and inventor of Thomas's splints.[br]Eldest son of a bone-setter, he studied at University College London, Edinburgh and Paris and became a member of the Royal College of Surgeons in 1857. Three years later he commenced practice in Liverpool, but he was never appointed to the staff of a hospital. Over the next twenty years he not only developed his own approach to orthopaedic practice, but also promoted a number of advances in other aspects of medicine such as epilepsy.Of a mechanical (as well as musical) bent of mind, he had his own workshop and over some twenty years developed his pattern of splints for fractures. In 1877 Rushton Parker, later Professor of Surgery at Liverpool, expressed his admiration of the splints. This led to the publication of their details and shortly after to their wide acceptance.Thomas's nephew Robert Jones was collaborating with him on a book on orthopaedics at the time of his death and went on to continue the tradition of what has been called the Liverpool School of orthopaedics.[br]Principal Honours and DistinctionsHonorary MD University of St Louis c. 1880.Bibliography1875, Diseases of the Hip, Knee and Ankle-joints.Further ReadingA.W.Beasley, 1982, The origins of orthopaedies', Journal of the Royal Society of Medicine 75.MG -
8 R.S.M.
abbreviationRegimental Sergeant-Major; Royal School of Mines; Royal Society of Medicine -
9 RSM
RSM [‚ɑ:res'em] -
10 Chamberlen (the Elder), Peter
SUBJECT AREA: Medical technology[br]b. c. 1601 London, Englandd. 22 December 1683 Woodham Mortimer, Essex, England[br]English obstetrician who was a member of a family of obstetricians of the same name who made use of a secret design of obstetric forceps (probably designed by him).[br]Of Huguenot stock, his ancestor William having probably come to England in 1569, he was admitted to Cambridge University in 1615 at the age of 14. He graduated Doctor of Medicine in Padua in 1619, having also spent some time at Heidelberg. In 1628 he was elected a Fellow of the College of Physicians, though with some reservations on account of his dress and conduct; these appear to have had some foundation for he was dismissed from the fellowship for repeated contumacy in 1659. Nonetheless, he was appointed Physician in Ordinary to Charles I in 1660. There are grounds for suspecting that in later years he developed some signs of insanity.Chamberlen was engaged extensively in the practice of midwifery, and his reputation and that of the other members of the family, several of whom were also called Peter, was enhanced by their possession of their own pattern of obstetric forceps, hitherto unknown and kept carefully guarded as a family secret. The original instruments were discovered hidden at the family home in Essex in 1815 and have been preserved by the Royal Society of Medicine. Chamberlen appears to have threatened the physicians' obstetric monopoly by attempting to organize mid-wives into a corporate company, to be headed by himself, a move which was successfully opposed by the College of Physicians.[br]Principal Honours and DistinctionsPhysician in Ordinary to King Charles I, King Charles II, King James II, Queen Mary and Queen Anne.Bibliography1662, The Accomplished Midwife. The Sober Mans Vindication, discovering the true cause and manner how Dr. Chamberlen came to be reported mad, London.Further ReadingMariceau, 1668, Des Malades des femmes grosses et accouchées, Paris. J.H.Aveling, 1883, The Chamberlens and the Midwifery Forceps, London.MGBiographical history of technology > Chamberlen (the Elder), Peter
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11 FRSM
Сокращение: Fellow of the Royal Society of Medicine -
12 RSM
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13 RSM
Королевское медицинское общество ( Великобритания) разведывательная стратегическая ракета -
14 Lister, Joseph, Baron Lister
SUBJECT AREA: Medical technology[br]b. 5 April 1827 Upton, Essex, Englandd. 10 February 1912 Walmer, Kent, England[br]English surgeon, founder of the antiseptic and aseptic principles of surgical practice.[br]Of Quaker stock, his father also being a Fellow of the Royal Society, he studied medicine at University College, London. He qualified, and became a Fellow of the Royal College of Surgeons, in 1852. Wishing to pursue a surgical career, he moved to Edinburgh to study surgery under William Syme, whose daughter he married in 1852, the same year he was appointed Assistant Surgeon to the Edinburgh Royal Infirmary.Until his appointment as Regius Professor of Surgery at Glasgow University and Glasgow Royal Infirmary in 1861, he was engaged in a wide variety of investigations into the nature of inflammation and the effects of irritants on wounds. Following his move to Glasgow, he became particularly involved in the major problems arising out of the vast increase in the number of surgical procedures brought about by the recent introduction of general anaesthesia. By 1865 his continuing study of wound inflammation and the microbial studies of Pasteur had led him to institute in the operating theatre a regime of surgical antisepsis involving the use of a carbolic acid spray coupled with the sterilization of instruments, the site of operation and the hands of the operator. Increasingly it was appreciated that the air was the least important origin of infection, and by 1887 the antiseptic approach had been superseded by the aseptic.In 1869 he succeeded Syme in the Chair at Edinburgh and his methods were widely accepted abroad. In 1877 he moved to the Chair of Surgery at King's College Hospital, London, in the hope of encouraging acceptance of his work in the metropolis. As well as developing a variety of new surgical procedures, he was engaged for many years in the development of surgical ligatures, which had always been a potent stimulant of infection. His choice of catgut as a sterilizable, absorbable material paved the way for major developments in this field. The Lister Institute of Preventive Medicine was named in his honour in 1903.[br]Principal Honours and DistinctionsCreated Baronet 1883. Baron 1897. Order of Merit 1902. President, Royal Society 1895– 1900.Bibliography1870, "On the effects of the antiseptic system of treatment upon the salubrity of a surgical hospital", Lancet.1859, Philosophical Transactions of the Royal Society.1863, Croonian Lecture.1881, 1900, Transactions of the International Medical Congress.Further ReadingR.J.Godlee, 1924, Lord Lister.1927, Lister Centenary Handbook, London: Wellcome Historical Medical Museum. H.C.Cameron, 1948, Joseph Lister, the Friend of Man.MGBiographical history of technology > Lister, Joseph, Baron Lister
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15 Hunter, John
SUBJECT AREA: Medical technology[br]b. 14 (registered 13) February 1728 East Kilbride, Lanarkshire, Scotlandd. 16 October 1793 London, England[br]Scottish surgeon and anatomist, pioneer of experimental methods in medicine and surgery.[br]The younger brother of William Hunter (1718–83), who was of great distinction but perhaps of slightly less achievement in similar fields, he owed much of his early experience to his brother; William, after a period at Glasgow University, moved to St George's Hospital, London. In his later teens, John assisted a brother-in-law with cabinet-making. This appears to have contributed to the lifelong mechanical skill which he displayed as a dissector and surgeon. This skill was particularly obvious when, after following William to London in 1748, he held post at a number of London teaching hospitals before moving to St George's in 1756. A short sojourn at Oxford in 1755 appears to have been unfruitful.Despite his deepening involvement in the study of comparative anatomy, facilitated by the purchase of animals from the Tower menagerie and travelling show people, he accepted an appointment as a staff surgeon in the Army in 1760, participating in the expedition to Belle Isle and also serving in Portugal. He returned home with over 300 specimens in 1763 and, until his appointment as Surgeon to St George's in 1768, was heavily involved in the examination of this and other material, as well as in studies of foetal testicular descent, placental circulation, the nature of pus and lymphatic circulation. In 1772 he commenced lecturing on the theory and practice of surgery, and in 1776 he was appointed Surgeon-Extraordinary to George III.He is rightly regarded as the founder of scientific surgery, but his knowledge was derived almost entirely from his own experiments and observations. His contemporaries did not always accept or understand the concepts which led to such aphorisms as, "to perform an operation is to mutilate a patient we cannot cure", and his written comment to his pupil Jenner: "Why think. Why not trie the experiment". His desire to establish the aetiology of gonorrhoea led to him infecting himself, as a result of which he also contracted syphilis. His ensuing account of the characteristics of the disease remains a classic of medicine, although it is likely that the sequelae of the condition brought about his death at a relatively early age. From 1773 he suffered recurrent anginal attacks of such a character that his life "was in the hands of any rascal who chose to annoy and tease him". Indeed, it was following a contradiction at a board meeting at St George's that he died.By 1788, with the death of Percival Pott, he had become unquestionably the leading surgeon in Britain, if not Europe. Elected to the Royal Society in 1767, the extraordinary variety of his collections, investigations and publications, as well as works such as the "Treatise on the natural history of the human teeth" (1771–8), gives testimony to his original approach involving the fundamental and inescapable relation of structure and function in both normal and disease states. The massive growth of his collections led to his acquiring two houses in Golden Square to contain them. It was his desire that after his death his collection be purchased and preserved for the nation. It contained 13,600 specimens and had cost him £70,000. After considerable delay, Par-liament voted inadequate sums for this purpose and the collection was entrusted to the recently rechartered Royal College of Surgeons of England, in whose premises this remarkable monument to the omnivorous and eclectic activities of this outstanding figure in the evolution of medicine and surgery may still be seen. Sadly, some of the collection was lost to bombing during the Second World War. His surviving papers were also extensive, but it is probable that many were destroyed in the early nineteenth century.[br]Principal Honours and DistinctionsFRS 1767. Copley Medal 1787.Bibliography1835–7, Works, ed. J.F.Palmer, Philosophical Transactions of the Royal Society, London.MG -
16 Franklin, Benjamin
[br]b. 17 January 1706 Boston, Massachusetts, USAd. 17 April 1790 Philadelphia, Pennsylvania, USA[br]American diplomat, statesman, scientist and inventor of bifocal spectacle lenses.[br]Described as a versatile genius, although less fairly also as an amateur dabbler, Franklin was of immediate English ancestry from Northamptonshire. During a long and prolific life, his innovations included the Franklin stove, arrangements for house ventilation and aeronautical and electrical experimentation. He was awarded the Copley Medal of the Royal Society in 1753 for his discoveries in relation to lighting conductors.His principal contribution to medicine was the invention of bifocal lenses constructed by the cementing of glass wafers to existing spectacle lenses. The date of this invention is uncertain, but was probably c.1774. A letter he wrote to a friend in 1775 refers to Peter Dollond, of the London optical firm, who has sometimes been thought to have contemporaneously developed some form of bifocal lens. Franklin's invention of the lens was prompted by his own visual difficulties.[br]Principal Honours and DistinctionsRoyal Medical Society of Paris 1777. Medical Society of London 1787. Royal Society Copley Medal 1753.Bibliography1888, The Life of Benjamin Franklin, Written by Himself, Philadelphia.Further ReadingC.van Dorek, 1938, Benjamin Franklin.H.Barty-King, 1986, Eyes Right, London.MG -
17 Wollaston, William Hyde
SUBJECT AREA: Metallurgy[br]b. 6 August 1766 East Dereham, Norfolk, Englandd. 22 December 1828 London, England[br]English chemist and metallurgist who discovered palladium and rhodium, pioneer in the fabrication of platinum.[br]Wollaston qualified in medicine at Cambridge University but gave up his practice in 1800 to devote himself to chemistry and metallurgy, funded from the profits from making malleable platinum. In partnership with Smithson Tennant, a friend from his Cambridge days, he worked on the extraction of platinum by dissolving it in aqua regia. In 1802 he found that in addition to platinum the solution contained a new metal, which he named palladium. Two years later he identified another new metal, rhodium.Wollaston developed a method of forming platinum by means of powder metallurgy and was the first to produce malleable and ductile platinum on a commercial scale. He produced platinum vessels for sulphuric acid manufacture and scientific apparatus such as crucibles. He devised an elegant method for forming fine platinum wire. He also applied his inventive talents to improving scientific apparatus, including the sextant and microscope and a reflecting goniometer for measuring crystal angles. In 1807 he was appointed Joint Secretary of the Royal Society with Sir Humphry Davy, which entailed a heavy workload and required them to referee all the papers submitted to the Society for publication.Wollaston's output of platinum began to decline after 1822. Due to ill health he ceased business operations in 1828 and at last made public the details of his secret platinum fabrication process. It was fully described in the Bakerian Lecture he delivered to the Royal Society on 28 November 1828, shortly before his death.[br]Principal Honours and DistinctionsFRS 1793.BibliographyHis scientific papers were published in various journals, nearly all listed in the Royal Society Catalogue of Scientific Papers.Further ReadingThere is no good general biography, the best general account being the entry inDictionary of Scientific Biography.D.McDonald, 1960, A History of Platinum from the Earliest Times to the Eighteen- Eighties, London (provides a good discussion of his work on platinum).M.E.Weeks, 1939, "The discovery of the elements", Journal of Chemical Education: 184–5.ASDBiographical history of technology > Wollaston, William Hyde
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18 Domagk, Gerhard Johannes Paul
SUBJECT AREA: Medical technology[br]b. 30 October 1895 Lagow, Brandenburg, Germanyd. 24 April 1964 Burgberg, Germany[br]German physician, biochemist and pharmacologist, pioneer of antibacterial chemotherapy.[br]Domagk's studies in medicine were interrupted by the outbreak of the First World War and his service in the Army, delaying his qualification at Kiel until 1921. For a short while he worked at the University of Greifswald, but in 1925 he was appointed Reader in Pathology at the University of Munster, where he remained as Extraordinary Professor of General Pathology and Pathological Anatomy (1928) and Professor (1958).In 1924 he published a paper on the role of the reticulo-endothelial system against infection. This led to his appointment as Director of Research by IG Farbenindustrie in their laboratory for experimental pathology and bacteriology. The planned programme of research into potential antibacterial chemotherapeutic drugs led, via the discovery of the dye Prontosil rubrum by his colleagues, to his reporting in 1936 the clinical antistreptococcal effects of the sulphonamide drugs. These results were confirmed in other countries, but owing to problems with the Nazi authorities he was unable to receive until 1947 the Nobel Prize that he was awarded in 1939.Domagk turned his interest to the chemotherapy of tuberculosis, and in 1946 he was able to report the therapeutic activity of the thiosemicarbazones, which, although too toxic for general use, in their turn led to the discovery of the potent and effective isoniazid. In his later years he moved into the field of cancer chemotherapy, but interestingly he wrote, "One should not have too great expectations of the future of cytostatic agents." His only daughter was one of the first patients to have a severe streptococcal infection successfully treated with Prontosil rubrum.[br]Principal Honours and DistinctionsNobel Prize for Medicine 1939. Foreign Member of the Royal Society. Paul Ehrlich Gold Medal.Bibliography1935, "Ein Beitrag zur Chemotherapie der bakteriellen Infektionen", Deutsche med. Woch.1924, Virchows Archiv für Path. Anat. und Physiol. u.f. klin. Med. 253:294–638.Further Reading1964, Biographical Memoirs of the Royal Society: Gerhard Domagk, London.MGBiographical history of technology > Domagk, Gerhard Johannes Paul
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19 Landsteiner, Karl
SUBJECT AREA: Medical technology[br]b. 14 June 1868 Vienna, Austriad. 26 June 1943 New York, USA[br]Austrian/American physician, physiologist and immunologist, discoverer of human blood groups.[br]He graduated in medicine from Vienna in 1891 and spent the next five years at various European universities. In 1923 he began to work at the Rockefeller Institute for Medical Research in New York. In 1900, while investigating the disintegration of red blood cells, he discovered the reaction of one person's cells to the serum of another. By 1909 he had developed the classification of four main blood groups, which has proved to be of fundamental importance, particularly in relation to the development of blood-transfusion techniques and blood banks, despite the later discovery of many subgroups as well as of the rhesus factor (1940) and its relation to miscarriages and neonatal disease.He was involved in research in many other fields, including syphilis, thyroid disease, scarlet fever and typhus, but his main studies were centred on the chemistry of immunology and its significance in allergy.[br]Principal Honours and DistinctionsNobel Prize for Medicine or Physiology 1930. Foreign member of the Royal Society.Bibliography1900, "Zur Kenntnis der Antifermentium, Lytischen und Agglutinierenden Werkungen des Blutserums und der Lymphe", Zbl. Bact.Further Reading1962, The Specificity of Serological Reactions, New York. 1945–8, Obituary Notices of Fellows of the Royal Society.MG -
20 Abel, John Jacob
SUBJECT AREA: Medical technology[br]b. 19 May 1857 near Cleveland, Ohio, USAd. 26 May 1938 Baltimore, Maryland, USA[br]American pharmacologist and physiologist, proponent of the "artificial kidney" and the isolator of pure insulin.[br]Born of German immigrant farming stock, his early scientific education at the University of Michigan, where he graduated PhB in 1883, suffered from a financially dictated interregnum of three years. In 1884 he moved to Leipzig and worked under Ludwig, moving to Strasbourg where he obtained his MD in 1888. In 1891 he was able to return to the University of Michigan as Lecturer in Materia Medica and Therapeutics, and in 1893 he was offered the first Chair of Pharmacology at Johns Hopkins University, a position he occupied until 1932. He was a pioneer in emphasizing the importance of chemistry, in its widest sense, in medicine and physiology. In his view, "the investigator must associate himself with those who have laboured in fields where molecules and atoms rather than multi-cellular tissues or even unicellular organisms are the units of study".Soon after coming to Baltimore he commenced work on extracts from the adrenal medulla and in 1899 published his work on epinephrine. In later years he developed an "artificial kidney" which could be used to remove diffusible substances from the blood. In 1913 he was able to demonstrate the existence of free amino-acids in the blood and his investigations in this field foreshadowed not only the developments of blood and plasma transfusion but also the possibility of the management of renal failure.From 1917 to 1924 he moved to a study of the hormone content of pituitary extracts, but in 1924 he suddenly transferred his attention to the study of insulin. In 1925 he announced the discovery of pure crystalline hormone. This work at first failed to gain full acceptance, but as late as 1955 the full elucidation of the protein structure of insulin proved the final culmination of his studies.Abel's dedication to laboratory research and his disdain for matters of administration may explain the relative paucity of worldy honours awarded to such an outstanding figure.[br]Principal Honours and DistinctionsFRS.Bibliography1913, "On the removal of diffusible substances from the circulating blood by means of dialysis", Transactions of the Association of American Physiologists.Further Reading1939, Obituary Notices, Fellows of the Royal Society, London: Royal Society.1946, Biographical Memoir: John Jacob Abel. 1857–1938, Washington, DC: National Academy of Sciences.MG
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